CAS Number 170381-16-5 DrugBank DB05828 KEGG D10329 Molar mass 354.9 g/mol ChemSpider ID 9640456 | PubChem CID 11465618 UNII QZV11V7G6A Formula C22H27ClN2 Pubchem 11465618 | |
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Zicronapine (zye-KRON-a-peen, previously known as Lu 31-130) is an atypical antipsychotic medication formerly under development by H. Lundbeck A/S. In phase II studies zicronapine showed statistically significant separation from placebo and convincing efficacy and safety data when compared to olanzapine.
Zicronapine exhibits monoaminergic activity and has a multi-receptorial profile. In vitro and in vivo it has shown potent antagonistic effects at dopamine D1, D2 and serotonin 5HT2A receptors.
In 2014 Lundbeck removed zicronapine from its development portfolio in favor of pursuing the more promising medicine Lu AF35700.
References
Zicronapine Wikipedia(Text) CC BY-SA