Zeno is a surname. Notable people with the surname include:
Reniero Zeno (fl. 1240–1268), Doge of Venice
The Zeno brothers (14th century), Nicolò and Antonio, Venetian navigators
Carlo Zeno (1333–1418), Venetian admiral
Pietro Zeno, Lord of Andros and Syros
Giovanni Battista Zeno (c. 1440 – 1501), Venetian cardinal
Nicolò Zeno (fl. 1558), Venetian cartographer and publisher of the Zeno map
Marco Zeno, commissioner of Palladio's Villa Zeno
Apostolo Zeno (1669–1750), Venetian poet and librettist
Muhammad bin Jamil Zeno (1922–2010), Syrian islamicist
Thierry Zéno (born 1950), Belgian filmmaker
Tony Zeno (born 1957), American basketball player
Mohamed Al Zeno (born 1983), Syrian footballer
