Zeno is a surname. Notable people with the surname include:
Reniero Zeno (fl. 1240–1268), Doge of VeniceThe Zeno brothers (14th century), Nicolò and Antonio, Venetian navigatorsCarlo Zeno (1333–1418), Venetian admiralPietro Zeno, Lord of Andros and SyrosGiovanni Battista Zeno (c. 1440 – 1501), Venetian cardinalNicolò Zeno (fl. 1558), Venetian cartographer and publisher of the Zeno mapMarco Zeno, commissioner of Palladio's Villa ZenoApostolo Zeno (1669–1750), Venetian poet and librettistMuhammad bin Jamil Zeno (1922–2010), Syrian islamicistThierry Zéno (born 1950), Belgian filmmakerTony Zeno (born 1957), American basketball playerMohamed Al Zeno (born 1983), Syrian footballer