Zeferino is a given name. Notable people with the name include:
Zeferino Paulo Borges (born 1978), Portuguese retired footballerJoão Zeferino da Costa (1840–1915), Brazilian painter and designerZeferino Martins (born 1985), East Timorese footballerZeferino Nandayapa (1931–2010), Mexican folk and classical marimba playerZeferino dos Prazeres, São Toméan politicianArmando Zeferino Soares, (1920–2007), Capeverdean composer, author of the famous song SodadeZeferino Torreblanca (born 1954), Mexican politician and former Governor of GuerreroZeferino González y Díaz Tuñón (1831–1894), Spanish Dominican theologian, and philosopher, Archbishop of Seville and CardinalZeferino Vaz (1908–1981), led the construction, establishment and development of the Unicamp university, State of São Paulo, BrazilAntónio Zeferino (born 1966), Cape Verdean athlete, specializing in long-distance running, marathon and half marathonJoão Zeferino (born 1981), Brazilian mixed martial artist