Zeferino is a given name. Notable people with the name include:
Zeferino Paulo Borges (born 1978), Portuguese retired footballer
João Zeferino da Costa (1840–1915), Brazilian painter and designer
Zeferino Martins (born 1985), East Timorese footballer
Zeferino Nandayapa (1931–2010), Mexican folk and classical marimba player
Zeferino dos Prazeres, São Toméan politician
Armando Zeferino Soares, (1920–2007), Capeverdean composer, author of the famous song Sodade
Zeferino Torreblanca (born 1954), Mexican politician and former Governor of Guerrero
Zeferino González y Díaz Tuñón (1831–1894), Spanish Dominican theologian, and philosopher, Archbishop of Seville and Cardinal
Zeferino Vaz (1908–1981), led the construction, establishment and development of the Unicamp university, State of São Paulo, Brazil
António Zeferino (born 1966), Cape Verdean athlete, specializing in long-distance running, marathon and half marathon
João Zeferino (born 1981), Brazilian mixed martial artist
