Zappalà is a surname. Notable people with the surname include:
Gregorio Zappalà (1833–1908), Italian sculptorStefano Zappalà (born 1941), Italian politician and Member of the European Parliament for Central with the Forza ItaliaStephen Zappala, Democratic politician and attorney who is the District Attorney of Allegheny County, PennsylvaniaVincenzo Zappalà (born 1945), Italian astronomer