Zappalà is a surname. Notable people with the surname include:
Gregorio Zappalà (1833–1908), Italian sculptor
Stefano Zappalà (born 1941), Italian politician and Member of the European Parliament for Central with the Forza Italia
Stephen Zappala, Democratic politician and attorney who is the District Attorney of Allegheny County, Pennsylvania
Vincenzo Zappalà (born 1945), Italian astronomer