Zangpo is a surname. Notable people with the surname include:
Karma Thubten Trinlay Gyurme Pal Zangpo, tulku in the Kagyu school of Tibetan Buddhism
Rinchen Zangpo (958–1055), principal translator of Sanskrit Buddhist texts into Tibetan
Rongzom Chokyi Zangpo, scholar of the Nyingma school of Tibetan Buddhism
Takna Jigme Zangpo (born 1926), spent thirty-seven years in a Chinese prison in Lhasa, Tibet as a political prisoner