Zanetti is an Italian surname. Notable people with the surname include:
Adriana Serra Zanetti (born 1976), Italian professional tennis playerAntonella Serra Zanetti (born 1980), Italian professional tennis playerAntonio Maria Zanetti (1679–1767), Venetian art critic, connoisseur and collectorArthur Zanetti (born 1990), Brazilian athleteCristiano Zanetti (born 1977), Italian professional football playerGiacomo Zanetti (1696–1735), Italian master builder and architectGianluca Zanetti (born 1977), Italian professional football playerGregory Zanetti, (contemporary), United States Army general officerJavier Zanetti (born 1973), Argentine professional football playerJosé Vela Zanetti (1913-1999), Spanish painter and muralistLorenzo Zanetti (born 1987), Italian motorcycle racerMarco Zanetti (born 1962), Italian professional billiards playerPaolo Zanetti (born 1982), Italian professional football playerPaul Zanetti (born 1961), Australian political cartoonistRicardo Zanetti (born 1975), United States Army Engineer Non-Commission OfficerRoberto Zanetti (born 1956), Italian singer and music producerSergio Zanetti (born 1967), Argentine professional football playerTom Zanetti (born 1989), English musician