Zanetti is an Italian surname. Notable people with the surname include:
Adriana Serra Zanetti (born 1976), Italian professional tennis player
Antonella Serra Zanetti (born 1980), Italian professional tennis player
Antonio Maria Zanetti (1679–1767), Venetian art critic, connoisseur and collector
Arthur Zanetti (born 1990), Brazilian athlete
Cristiano Zanetti (born 1977), Italian professional football player
Giacomo Zanetti (1696–1735), Italian master builder and architect
Gianluca Zanetti (born 1977), Italian professional football player
Gregory Zanetti, (contemporary), United States Army general officer
Javier Zanetti (born 1973), Argentine professional football player
José Vela Zanetti (1913-1999), Spanish painter and muralist
Lorenzo Zanetti (born 1987), Italian motorcycle racer
Marco Zanetti (born 1962), Italian professional billiards player
Paolo Zanetti (born 1982), Italian professional football player
Paul Zanetti (born 1961), Australian political cartoonist
Ricardo Zanetti (born 1975), United States Army Engineer Non-Commission Officer
Roberto Zanetti (born 1956), Italian singer and music producer
Sergio Zanetti (born 1967), Argentine professional football player
Tom Zanetti (born 1989), English musician
