Zamudio is a surname. Notable people with the surname include:
Adela Zamudio (1854-1928), Bolivian poet
Daniel Zamudio (1987-2012), Chilean man murdered in 2012.
Gustavo Zamudio (born 1985), Chilean footballer
Héctor Fix-Zamudio (born 1942), Mexican jurist
Ignacio Zamudio (born 1971), Mexican race walker
José Mario Carrillo Zamudio (born 1956), Mexican football coach
Raúl Zamudio, American art critic