Zakharchenko is a surname. Notable people with the surname include:
Aleksandr Zakharchenko, Ukrainian pro-Russian separatist leader
Lyubov Zakharchenko, Russian poet and singer-songwriter
Stanislav Zakharchenko, Russian footballer
Vitaliy Zakharchenko, Ukrainian government minister (suspended from duties by the Ukrainian parliament)
Yevgeni Zakharchenko, Russian footballer