CAS Number 219923-05-4 Formula C20H24NO8P Molar mass 437.38 g/mol ChemSpider ID 8072099 | UNII GBO3S6M9W7 3D model (Jmol) Interactive image PubChem CID 9896434 | |
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Synonyms ANG 453; AZD 6126; N-Acetylcolchicinol dihydrogenphosphate | ||
ZD6126 is a vascular-targeting agent and a prodrug of N-acetylcolchinol, related to colchicine. It has shown promising results on tumors in mice.
A phase I clinical trial identified gastrointestinal and cardiac effects as limiting dosing. Two phase II clinical trials were started investigating ZD6126 in metastatic renal cell carcinoma and metastatic colorectal cancer.
ZD6126 was being investigated by AstraZeneca as a vascular disrupting agent (VDA). However, the trials were halted, after it became apparent that ZD6126 was too cardiotoxic at the required doses.
References
ZD6126 Wikipedia(Text) CC BY-SA