Entrez 51776 | Ensembl ENSG00000091436 | |
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Aliases MAP3K20, AZK, MLK7, MLT, MLTK, MRK, mlklak, pk, ZAK, SFMMP, sterile alpha motif and leucine zipper containing kinase AZK External IDs MGI: 2443258 HomoloGene: 32331 GeneCards: MAP3K20 |
Sterile alpha motif and leucine zipper containing kinase AZK, also known as ZAK, is a human gene.
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Interactions
ZAK has been shown to interact with ZNF33A.
References
ZAK Wikipedia(Text) CC BY-SA