Yusupov (Russian: Юсупов) or Yusupova (feminine; Юсупова) is a Russian surname. It may refer to:
House of Yusupov, noble Russian family
Felix Yusupov (1887–1967), Count Sumarokov-Elston, Russian aristocrat and one of the participants in the murder of Grigori Rasputin
Irina Yusupova (1915–1993), Russian Princess and daughter of Count Felix Yusupov
Zinaida Nikolaevna Yusupova (1861–1939), Russian Princess and mother of Count Felix Yusupov
Aliya Yusupova (b. 1984), Kazakhstan gymnast
Artur Yusupov (b. 1960), chess grandmaster
Benjamin Yusupov (born 1962), Israeli composer of Tajik origin
Iosef Yusupov (born 1955), American set designer born in Samarkand
Ismail Yusupov (1913–2005), Kazakhstan politician
Iraida Yusupova (b. 1962), Turkmenistan composer
Lidia Yusupova (b. 1961), human rights activist
Tuti Yusupova (b. 1880?), Uzbekistani longevity claimant
