Yoshitsugu is a masculine Japanese given name. Notable people with the name include:
Hatakeyama Yoshitsugu (1552–1586), Japanese daimyo of the Sengoku period, 14th head of the Nihonmatsu clan of Mutsu
Maeba Yoshitsugu (1541–1574), retainer beneath the clan of Asakura throughout the late Sengoku period of Feudal Japan
Miyoshi Yoshitsugu, samurai of the Sengoku period who was practically the last head of Miyoshi clan
Otani Yoshitsugu (1559–1600), Japanese samurai of the Sengoku period though Azuchi-Momoyama Period
Tokugawa Yoshitsugu (1836–1849), Japanese daimyo of the Edo period, who ruled the Owari Domain
Yoshitsugu Harada (born 1952), Japanese politician of the Liberal Democratic Party, a member of the House of Representatives in the Diet
Yoshitsugu Matsuoka Japanese voice actor from Hokkaido, Japan.
Yoshitsugu Saito (1890–1944), lieutenant general in the Imperial Japanese Army during World War II