Yoshihisa is a masculine Japanese given name. Notable people with the name include:
Amago Yoshihisa (1540–1610), Japanese warlord
Ashikaga Yoshihisa (1465–1489), 9th shogun of the Ashikaga shogunate
Prince Kitashirakawa Yoshihisa (1847–1895), the 2nd head of a collateral branch of the Japanese imperial family
Shimazu Yoshihisa (1533–1611), daimyo of Satsuma Province and the eldest son of Shimazu Takahisa
Yoshihisa Furukawa (born 1965), Japanese politician of the Liberal Democratic Party
Yoshihisa Hirano (born 1971), Japanese composer
Yoshihisa Taira (1937–2005), Japanese-born French composer
Yoshihisa Hirano (baseball) (born 1984), professional Japanese baseball player
Yoshihisa Inoue (born 1947), Japanese politician of the New Komeito Party
Yoshihisa Ishida (born 1944), retired male shot putter and hammer thrower from Japan
Yoshihisa Naruse (born 1985), pitcher for the Chiba Lotte Marines of Nippon Professional Baseball
Yoshihisa Tabuchi, the president of Nomura Securities between 1985 and 1991
Yoshihisa Yamamoto (scientist) (born 1950), Japanese scientist and engineer
Yoshihisa Yamamoto (wrestler) (born 1970), Japanese professional mixed martial arts competitor and professional wrestler