Yanofsky is a surname. Notable people with the surname include:
Charles Yanofsky (born 1925), leading American geneticist
Daniel Yanofsky, OC, QC (1925–2000), Canada's first chess grandmaster
Joel Yanofsky, Canadian novelist and literary columnist
Nikki Yanofsky (born 1994), Canadian jazz-pop singer-songwriter from Montreal, Quebec
Saul Yanofsky or Saul Yanovsky (1864–1939), American Jewish anarchist and activist
Zal Yanofsky or Zal Yanovsky (1944–2002), Canadian rock musician
