XPO5

Exportin-5 (XPO5) is a protein that in humans is encoded by the XPO5 gene.

Exportin-5 is a member of the karyopherin family. In metazoa, it is involved in transport of pre-microRNA out of the nucleus, where such molecules are generated by the Microprocessor complex, and into the cytoplasm for further processing by the Dicer enzyme.

The plant homolog is called HASTY; although it is known to be required for the miRNA biogenesis pathway, its role in nuclear export is less clear than it is in animals.