Formula C23H13F9N4O3S | PubChem CID 6918788 | |
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XCT790 is a potent and selective inverse agonist ligand of the estrogen-related receptor alpha. Independent of its inhibition of ERRĪ±, XCT790 is a potent mitochondrial electron transport chain uncoupler.
Mitochondrial electron transport chain uncoupling effect
XCT790 has been shown to uncouple oxygen consumption from ATP production in mitochondria at very low, nanomolar-range doses independently of ERRĪ± expression. Its effects are similar to proton ionophores such as FCCP, which disrupt mitochondrial transmembrane electrochemical gradients. This uncoupling leads to a fast drop in ATP production and, consequently, a prompt activation of AMPK.
References
XCT790 Wikipedia(Text) CC BY-SA