Supriya Ghosh (Editor)

XCR1

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Species
  
Entrez
  
2829

Human
  
Ensembl
  
ENSG00000173578

XCR1

Aliases
  
XCR1, CCGPR5, X-C motif chemokine receptor 1

External IDs
  
MGI: 1346338 HomoloGene: 21095 GeneCards: XCR1

The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2 (or lymphotactin-1 and -2).

XCR1 is also known as GPR5.

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

References

XCR1 Wikipedia


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