Species Human Entrez 653067 | Human Mouse Ensembl n/a | |
Aliases XAGE1E, CT12.1, CT12.1C, CT12.1D, CT12.1E, CTP9, GAGED2, XAGE-1, XAGE1, XAGE1C, XAGE1D, X antigen family member 1E External IDs HomoloGene: 135786 GeneCards: XAGE1E | ||
G antigen family D member 2 is a protein that in humans is encoded by the XAGE1D gene.
This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 3 transcript variants, and one of which includes 2 transcripts generated from alternate transcription initiation sites.