Wylie is a surname. Notable people with the surname include:
Adam WylieAlexander Wylie (disambiguation), multiple peopleAndrew Wylie, first president of Indiana UniversityAndrew Wylie (literary agent), American literary agentBen Wylie, Irish cricketerChalmers WylieCharles Hotham Montagu Doughty-WylieCraig WylieElinor WylieFannie B. Wylie, American politicianSir Francis James Wylie (1865–1952), British academic literary criticSir Francis Verner Wylie (1891–1970), British civil servant in IndiaGraham Wylie, Founder of the Sage GroupIda Alexa Ross Wylie (1885-1959), Australian/British/American writerJames Aitken Wylie, Scottish historianMike Wylie, Australian rugby league footballerMina WylieNorman WyliePaul WyliePete WyliePhilip Gordon WylieRichard "Popcorn" Wylie (1939-2008), American R&B pianist, songwriter and record producerRobert WylieShaun WylieWillard Otis Wylie (1862–1944), of Boston, Massachusetts, USAWilliam M. Wylie, American politician