Wylie is a surname. Notable people with the surname include:
Adam Wylie
Alexander Wylie (disambiguation), multiple people
Andrew Wylie, first president of Indiana University
Andrew Wylie (literary agent), American literary agent
Ben Wylie, Irish cricketer
Chalmers Wylie
Charles Hotham Montagu Doughty-Wylie
Craig Wylie
Elinor Wylie
Fannie B. Wylie, American politician
Sir Francis James Wylie (1865–1952), British academic literary critic
Sir Francis Verner Wylie (1891–1970), British civil servant in India
Graham Wylie, Founder of the Sage Group
Ida Alexa Ross Wylie (1885-1959), Australian/British/American writer
James Aitken Wylie, Scottish historian
Mike Wylie, Australian rugby league footballer
Mina Wylie
Norman Wylie
Paul Wylie
Pete Wylie
Philip Gordon Wylie
Richard "Popcorn" Wylie (1939-2008), American R&B pianist, songwriter and record producer
Robert Wylie
Shaun Wylie
Willard Otis Wylie (1862–1944), of Boston, Massachusetts, USA
William M. Wylie, American politician
