Wyche is a surname, and may refer to:
C. Thomas Wyche (1926-2015), American lawyer and conservationist
Charles Cecil Wyche (1885-1966), judge
Cyril Wyche (1632-1707), president of the Royal Society
Cyril Wyche (1695-1756), 1st Baronet, Ambassador to Russia
James Wyche (b. 1982), American football player
Jane Wyche (17th century), countess of Bath
Monty M. Wyche (1926-2014), American jurist
Nathaniel Wyche (1607-1659), president of the English East India Company
Peter Wyche (1593-1643), English Ambassador to the Ottoman Empire
Peter Wyche (1628-1699), English Ambassador to Russia and Poland
Richard Wyche (1197-1253), Saint and Bishop of Chichester
Richard Wyche (1554-1621), director of the English East India Company
Sam Wyche (b. 1945), former American football player
Zelma Wyche (1918-1999), Louisiana politician and African-Americana civil rights activist
