Worthen is a surname. Notable people with the surname include:
Amos Henry Worthen, American geologist
Clyde Worthen, American judoka
Joey Worthen (born 1979), American soccer player
John Worthen, English academic, literary critic and biographer
John E. Worthen (born 1933), American university president
Kevin J Worthen (born 1957), American lawyer and BYU president
Molly Worthen (born 1981), American writer
Sam Worthen (born 1958), American basketball player
Shawn Worthen (born 1978), American football player
