Woodruff is a surname. Notable people with the surname include:
Abraham O. Woodruff (1872–1904), member of the Quorum of the Twelve Apostles of The Church of Jesus Christ of Latter-day Saints, and son of Wilford Woodruff
Blake Woodruff (born 1995), actor
Bille Woodruff, video and film director
Bob Woodruff, an American journalist
Bob Woodruff (American football) former University of Florida and Baylor University head football coach
Bob Woodruff (singer), American country musician
Bobby Woodruff (born 1940), former professional footballer
Carle Augustus Woodruff (1841–1913), U.S. Army brigadier general and Medal of Honor recipient
C. E. Woodruff, American reverend, educator, and college football coach
Chris Woodruff (born 1973), American tennis player
Christian B. Woodruff (born 1829), New york politician
Dwayne Woodruff (born 1957), American football player
Elvira Woodruff (born 1951), American children's writer
Ernest Woodruff (1863–1944), Atlanta businessman who took over Coca-Cola
Freddie Woodruff, American officer
George Cecil Woodruff, an American businessman and football coach
George Washington Woodruff, an American football coach as well as a teacher, lawyer and politician
Hale Woodruff (1900–1980), American painter
John Woodruff (representative) (1826–1868), was a U.S. Congressman from Connecticut
John Woodruff (1915–2007), American 1936 Olympic gold metal 800 meter runner
JT Woodruff, guitarist and lead vocalist of Hawthorne Heights
Judy Woodruff, a TV journalist
Lewis Bartholomew Woodruff (1809–1875), New York judge
Maurice Woodruff (1916–1973), a British clairvoyant and astrologer
Michael Woodruff, a pioneer in transplantation biology and surgery
Paul Woodruff, philosophy and classics professor, University of Texas at Austin
Richard Woodruff (Upper Canada politician) (1784–1872)
Robert Woodruff (disambiguation), several people
Rosalie Woodruff, Australian politician
Roscoe B. Woodruff (1891–1975), American general
Roy O. Woodruff (1876–1953), U.S. Representative from Michigan
Sarah Woodruff, the main character of The French Lieutenant's Woman
Thomas M. Woodruff (1804–1855), U.S. Congressman from New York
Thomas Tuttle Woodruff (1811–1892), Woodruff Sleeping & Palace Car Company, Central Transportation Company, Woodruff Sleeping & Parlor Coach Company, Union Palace Car Company
Timothy L. Woodruff (1858–1913), Lieutenant Governor of New York
William Woodruff (disambiguation), several people
Wilford Woodruff, fourth President of The Church of Jesus Christ of Latter-day Saints
