Wolpe is a locational surname of German origin, named after the medieval County of Wölpe. It may refer to:
Berthold Wolpe (1905–1989), German visual designer
David Wolpe (born 1958), American rabbi
Harold Wolpe (1926–1996), South African economist
Howard Wolpe (1939–2011), American politician
Joseph Wolpe (1915–1997), South African psychiatrist
Lenny Wolpe (born 1951), American actor
Paul Root Wolpe (born 1957), American sociologist
Sholom Ber Wolpe (born 1948), Israeli rabbi
Sholeh Wolpe (born 1962), Iranian poet and literary translator
Stefan Wolpe (1902–1972), American composer
