Wirths is a German surname. Notable people with the surname include:
Carl Wirths (1897–1955), German politicianEduard Wirths (1909–1945), Nazi German SS doctor at Auschwitz concentration camp during World War IIGünter Wirths (1911–2005), German chemistHarold J. Wirths, politician, Commissioner of the New Jersey Department of Labor and Workforce Development (2010–present).Wallace R. Wirths (1921–2002), former Westinghouse executive, author, newspaper columnist and radio commentator, and benefactor of Upsala College