Wilkie is a surname of British origin, which is medieval pet form of the personal name William. An alternative spelling is Wilkey, and a related German surname is Wilke. The surname Wilkie may refer to:
Alan Wilkie (born 1951), British football referee
Allan Wilkie (1878–1970), British actor
Alex Wilkie (born 1948), British mathematician
Alexander Wilkie (1850–1928), British politician
Andrew Wilkie (born 1961), Australian politician
Bob Wilkie (born 1969) Canadian ice hockey player
Clare Wilkie (born 1974), British actress
David Wilkie (artist) (1785–1841), British painter
David Wilkie (ice hockey) (born 1974), American ice hockey player
David Wilkie (surgeon) (1882–1938), British surgeon
David Wilkie (swimmer) (born 1958), British swimmer
Dougie Wilkie (born 1956), Scottish footballer
Douglas Wilkie (1909–2002), Australian journalist
Eli Wilkie (born 1968), American DJ and record producer
Gordon Wilkie (born 1940), Canadian ice hockey player
Horace W. Wilkie (1917–1976), American politician
Ian Angus Wilkie (born 1960), British actor
J. Scott Wilkie, Canadian lawyer
Jean Baptiste Wilkie (1803–1886), American Métis chief
John Wilkie (1860–1934), American journalist and intelligence officer
John Wilkie (canoer) (born 1977), Australian slalom canoer
John Wilkie (footballer) (born 1947), Scottish footballer
Kim Wilkie (born 1959), Australian politician
Kyle Wilkie (born 1991), Scottish footballer
Lee Wilkie (born 1980), Scottish footballer
Lefty Wilkie (1914–1992) American baseball player
Leslie Wilkie (1878–1935), Australian artist
Malcolm Richard Wilkey (1918–2009), American judge and diplomat
Philip Willkie (1919–1974), American businessman
Reginald Wilkie (1907–1962), British ice dancer
Rob Wilkey (born 1956), American politician
Robert Wilkie (born 1963), American lawyer
Robert J. Wilke (1914–1989), American actor
Vincent Wilkie (born 1969), German musician
Wendell Willkie (1892–1944), American lawyer and politician
William Wilkie (1721–1772), Scottish poet
