Wilkens is a surname. Notable people with the surname include:
Andrea Wilkens (born 1984), German footballer
Carl Wilkens (born c. 1957), American involved in genocide rescue efforts
Elmer Wilkens (1901–1967), American football player who played in the National Football League
Henry Wilkens (1855–1895), American Medal of Honor recipient
Iman Wilkens (born 1936), author of Where Troy Once Stood
Jan Wilkens (born 1943), South African wrestler
Lenny Wilkens (born 1937), American basketball player and coach
Piter Wilkens (born 1959), Dutch musician
Theodoor Wilkens (1690–1748), painter from the Northern Netherlands
Tom Wilkens (born 1975), American competitive swimmer
Toni Wilkens (born 1962), Swedish actor
Wilhelm Wilkens (1893–1967), Swedish rower