Wickremasinghe or Wickramasinghe is a Sinhalese surname. Notable people with the surname include:
Chandra Wickramasinghe (born 1939), British mathematician and astronomer
Don Martino de Zilva Wickremasinghe (died 1937), Ceylonese epigraphist and archeologist
Doreen Young Wickremasinghe, Ceylonese politician
Gamini Wickremasinghe (born 1965), Sri Lankan cricketer
Jagath Wickramasinghe (born 1966), Sri Lankan musician
Lakshman Wickremasinghe (1927–1983), Sri Lankan priest
M. Wickramasinghe, Sri Lankan banker
Maitree Wickramasinghe, Sri Lankan academic
Martin Wickramasinghe (1890–1976), Ceylonese author
Neela Wickramasinghe (born 1954), Sri Lankan singer
Neranjan Wickremasinghe, Sri Lankan politician
Nira Wickramasinghe (born 1964), Sri Lankan academic
Pramodya Wickramasinghe (born 1971), Sri Lankan cricketer
Ranil Wickremasinghe (born 1949), Sri Lankan politician
S. A. Wickramasinghe (1901–1981), Ceylonese politician
Shelley Wickramasinghe (1926–2011), Sri Lankan cricket official
Sunitha Wickramasinghe, British physician and academic
Udaya Wickramasinghe (1939–2010), Sri Lankan cricket official
Umayangana Wickramasinghe (born 1980), Sri Lankan actress