Weekes is a surname. Notable people with the surname include:
Ambrose Weekes (1919–2012), British priest, bishop of Gibraltar
Anthony Weekes, English Member of Parliament in 1563
Claire Weekes (1903–1990), Australian general practitioner and health writer
Dallon Weekes (born 1981), American musician, singer, and songwriter.
Dan Weekes-Hannah (born 1987), New Zealand-born actor
Donald Weekes (born 1930), former English cricketer
Elias Weekes (1809–1881), Australian ironmonger and politician
Sir Everton Weekes (born 1925), leading former West Indian cricketer
Hampton Weekes (1880–1948), English priest who was Archdeacon of the Isle of Wight
Harold Weekes (1880–1950), American football player
Henry Weekes (1807–1877), English sculptor of the mid-Victorian period
Herbert William Weekes (fl. 1864–1904), English genre and animal painter of the Victorian Neoclassical period
James Weekes (1911–1977), American sailor and Olympic champion
Ken Weekes (1912–1998), West Indian cricketer
Kevin Weekes (born 1975), retired Canadian ice hockey goaltender
Lesroy Weekes (born 1971), West Indian cricketer who played for the Leeward Islands and English counties
Liz Weekes (born 1971), Australian water polo player and Olympic champion
Nick Weekes (born 1981), former English cricketer
Paul Weekes (born 1969), former English cricketer
Randy Weekes (born 1956), Canadian politician
William Weekes (died 1806), lawyer and political figure in Upper Canada