Weddle is a surname. Notable people with the surname include:
Chris Weddle (born 1983), bodhrán player and instructor
David Weddle, American television producer and writer
Eric Weddle (born 1985), American football player
Jack Weddle (1905–1979), English footballer
James D. Weddle, American businessman
Mary Weddle (born 1934), All-American Girls Professional Baseball League player
Mat Weddle (born 1983), American singer-songwriter who uses the stage name Obadiah Parker
Thomas Weddle (1817–1853) English mathematician who introduced the Weddle surface.