Weddle is a surname. Notable people with the surname include:
Chris Weddle (born 1983), bodhrán player and instructorDavid Weddle, American television producer and writerEric Weddle (born 1985), American football playerJack Weddle (1905–1979), English footballerJames D. Weddle, American businessmanMary Weddle (born 1934), All-American Girls Professional Baseball League playerMat Weddle (born 1983), American singer-songwriter who uses the stage name Obadiah ParkerThomas Weddle (1817–1853) English mathematician who introduced the Weddle surface.