Wake is a surname. Notable people with the surname include:
Brian Wake (born 1982), English footballerCameron Wake (born 1982), American football linebackerDavid B. Wake (born 1936), biologist and herpetologistHarry Wake (1901–1981), English footballerHereward the Wake (born 1035), 11th-century Anglo-Saxon leaderIsaac Wake (1580–1632), English diplomat and political commentatorJohn Wake (born 1953), English cricketerMargaret Wake, 3rd Baroness Wake of Liddell (1297–1349), wife of Edmund of Woodstock, 1st Earl of KentMarvalee Wake (born 1939), American biologistNancy Wake (1912–2011), New Zealand born Australian who served as a British spy during World War IINeil Vincent Wake (born 1948), United States federal judgeRic Wake, record producerRobert A. Wake, 1966 champion of the Scripps National Spelling BeeThomas Wake, 2nd Baron Wake of Liddell (1297–1349), English baronWilliam Wake (1657–1737), Archbishop of CanterburyWilliam Wake (cricketer) (1852–1896), English amateur first-class cricketerWilliam Wake (governor), governor of Bombay