Waghorn is a surname. Notable people with the surname include:
Alexander de Waghorn (died 1418?), Roman Catholic Bishop of Ross
Eduardo Waghorn (born 1966), Chilean musician
H. T. Waghorn (1842–1930), cricket statistician and historian
Kerry Waghorn (born 1947), syndicated caricaturist
Martin Waghorn, officer of the Royal Navy
Martyn Waghorn (born 1990), English footballer who plays for Rangers as a striker
Richard Waghorn (1904–1931), English aviator, Royal Air Force pilot and 1929 Schneider Trophy seaplane race winner
Thomas Fletcher Waghorn (1800–1850), a postal pioneer