Waddel is a surname. Notable people with the surname include:
James Waddel (1739–1805), Irish American Presbyterian preacher from VirginiaJames Waddel Alexander (1804–1859), American Presbyterian minister and theologianJohn Newton Waddel, Chancellor of the University of Mississippi from 1865 to 1874Moses Waddel (1770–1840), American educator and minister in antebellum Georgia and South Carolina