Entrez 11197 | Ensembl ENSG00000156076 | |
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Aliases WIF1, WIF-1, WNT inhibitory factor 1 External IDs MGI: 1344332 HomoloGene: 31430 GeneCards: WIF1 | ||
Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene. WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.
Function
WNT proteins are extracellular signaling molecules involved in the control of embryonic development. This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.
References
WIF1 Wikipedia(Text) CC BY-SA