Aliases WDR47 Human Mouse Ensembl ENSG00000085433 | Species Human Entrez 22911 | |
External IDs MGI: 2139593 HomoloGene: 8984 GeneCards: WDR47 | ||
WD repeat domain 47 is a protein that in humans is encoded by the WDR47 gene.
Model organisms
Model organisms have been used in the study of WDR47 function. A conditional knockout mouse line, called Wdr47tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty-six tests were carried out on mutant mice and three significant abnormalities were observed. Homozygous mutant animals had an absence of corpus callosum and increased circulating alkaline phosphatase levels. Male homozygous mice also had abnormal indirect calorimetry measures.