ATC code none IUPHAR/BPS 3240 Formula C15H13ClN4O2S2 Molar mass 380.872 g/mol ChEMBL ID 392760 IUPHAR/BP 3240 | CAS Number 554403-49-5 UNII WXE3H7W295 3D model (Jmol) Interactive image PubChem CID 10150497 ChemSpider ID 8326005 | |
WAY-181,187 is a high affinity and selective 5-HT6 receptor full agonist. It induces robust increases in extracellular GABA levels in the frontal cortex, hippocampus, striatum, and amygdala of rats without affecting concentrations in the nucleus accumbens or thalamus, and has modest to no effects on norepinephrine, serotonin, dopamine, or glutamate levels in these areas. WAY-181,187 has demonstrated preclinical efficacy in rodent models of depression, anxiety, and notably obsessive-compulsive disorder, though it has also been shown to impair cognition and memory.
References
WAY-181,187 Wikipedia(Text) CC BY-SA