PubChem CID 145949 3D model (Jmol) Interactive image Density 1.4 g/cm³ ChemSpider ID 128749 Boiling point 536.52 °C (997.74 °F) | ChEMBL CHEMBL403272 Molar mass 283.28 g/mol Melting point 86–88 °C (187–190 °F) Formula C16H13NO4 | |
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Virstatin is a small molecule that inhibits the activity of the cholera protein, ToxT.
Its activity in cholera was first published in 2005 in a paper that described the screening of a chemical library in a phenotypic screen and subsequent testing of one of the hits in infected mice.
The compound is an isoquinoline alkaloid and can be synthesized by reacting 1,8-napthalic anhydride with 4-amino-n-butyric acid or by a simple two-step synthesis
References
Virstatin Wikipedia(Text) CC BY-SA