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Vinorine synthase

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EC number
  
2.3.1.160

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
88844-97-7

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a vinorine synthase (EC 2.3.1.160) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + 16-epivellosimine CoA + vinorine

Thus, the two substrates of this enzyme are acetyl-CoA and 16-epivellosimine, whereas its two products are CoA and vinorine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:16-epivellosimine O-acetyltransferase (cyclizing). This enzyme participates in indole and ipecac alkaloid biosynthesis.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2BGH.

References

Vinorine synthase Wikipedia


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