Vinorine hydroxylase

In enzymology, a vinorine hydroxylase (EC 1.14.13.75) is an enzyme that catalyzes the chemical reaction

The 4 substrates of this enzyme are vinorine, NADPH, H⁺, and O₂, whereas its 3 products are vomilenine, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is vinorine,NADPH:oxygen oxidoreductase (21alpha-hydroxylating). This enzyme participates in indole and ipecac alkaloid biosynthesis.