Vetispiradiene synthase

In enzymology, a vetispiradiene synthase (EC 4.2.3.21) is an enzyme of Egyptian henbane that catalyzes the following chemical reaction:

Hence, this enzyme has one substrate, trans,trans-farnesyl diphosphate, and two products, vetispiradiene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming). Other names in common use include vetispiradiene-forming farnesyl pyrophosphate cyclase, pemnaspirodiene synthase, HVS, and vetispiradiene cyclase. This enzyme participates in terpenoid biosynthesis.