CAS Number 22232-64-0 IUPHAR/BPS 4759 3D model (Jmol) Interactive image Pubchem 5662 ChemSpider ID 5460 | PubChem CID 5662 Formula C17H25NO Molar mass 259.39 g/mol ChEMBL ID 20730 IUPHAR/BP 4759 | |
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Vesamicol is an experimental drug, acting presynaptically by inhibiting acetylcholine (ACh) uptake into synaptic vesicles and reducing its release. Vesamicol may have applications in BAC therapy. It has been described as a hydroxylated phencyclidine regioisomer.
Mechanism of action
Vesamicol can be broadly categorized as a cholinergic physiological antagonist, because it reduces the apparent activity of cholinergic neurons, but does not act at the postsynaptic ACh receptor. Vesamicol causes a non-competitive and reversible block of the intracellular transporter VAChT responsible for carrying newly synthesized ACh into secretory vesicles in the presynaptic nerve terminal. This transport process is driven by a proton gradient between cell organelles and the cytoplasm. Blocking of acetylcholine loading leads to empty vesicles fusing with neuron membranes, decreasing ACh release.