Vellosimine dehydrogenase

In enzymology, a vellosimine dehydrogenase (EC 1.1.1.273) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are 10-deoxysarpagine and NADP⁺, whereas its 3 products are vellosimine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 10-deoxysarpagine:NADP⁺ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.