Vedel is a surname. Notable people with the surname include:
Anders Sørensen Vedel (1542–1616), priest and historian born in Vejle, DenmarkArtemy Vedel (1767–1808), 18th century Ukrainian composerDominique Honoré Antoine Vedel (1771–1848), French generalGeorges Vedel (1910–2002), French public law professor from Auch, FranceKristian Solmer Vedel (1923–2003), Danish industrial designer and part of the Scandinavian Design movementAlexandre-Louis Poulet, called Vedel, French dramatist