Vassallo is a surname. Notable people with the surname include:
Andrea Vassallo (born 1997), Italian footballer
Ángel Daniel Vassallo (born 1986), Puerto Rican basketball player
Angelo Vassallo (1953–2010), Italian politician
Antonio Maria Vassallo (c. 1620–1664/1673), Italian Baroque painter
Barrie Vassallo (born 1956), Welsh footballer
Ġan Anton Vassallo (1817–1868) Maltese writer, poet and academic
Gustavo Vassallo (born 1978), Peruvian footballer
Gustavo Vassallo (fencer) (born 1920), Argentine fencer
Harry Vassallo, Maltese politician
Jesse Vassallo (born 1961), Puerto Rican swimmer
Joseph Vassallo (born 1964), American actor
Martín Vassallo Argüello (born 1980), Argentine tennis player
Nicla Vassallo (born 1963), Italian philosopher and writer
Salvador Vassallo (businessman) (1942–2007), Puerto Rican businessman
Salvador Vassallo (swimmer) (born 1968), Puerto Rican swimmer
Stephen Vassallo (born 1983), Canadian mathlete