Vane is a surname. Notable people with the surname include:
Charles Vane (c.1680–1721), English pirate who preyed upon English and French shipping. His pirate career lasted from 1716–1719
Charles Vane-Tempest-Stewart, 6th Marquess of Londonderry (1852–1915), British Conservative politician
Charles Vane-Tempest-Stewart, 7th Marquess of Londonderry (1878–1949), Secretary of State for Air in the 1930s, in favour of the appeasement policy towards Nazi German
Christopher Vane, 1st Baron Barnard (1653–1723), English peer known for his treatment of his heirs, and his employment as steward of Peter Smart; father of the poet Christopher Smart
Edith Vane-Tempest-Stewart, Marchioness of Londonderry (1878–1959), a noted socialite and philanthropist in the United Kingdom between World War I and World War II
Sir Francis Vane, Baronet, (1861–1934), early aide of Lord Baden-Powell's and a Scout Commissioner of London before Baden-Powell ousted him from the Scout Association; founder of the Order of World Scouts, the earliest multinational Scouting movement
George Vane-Tempest, 5th Marquess of Londonderry (1821–1884), Anglo-Irish aristocrat, businessman and Conservative politician
Harry Vane, 11th Baron Barnard (born September 21, 1923), British peer, the son of Christopher Vane, 10th Baron Barnard
Henry Vane:
Sir Henry Vane the Elder (1589–1655), English courtier, father of Henry Vane the Younger
Sir Henry Vane the Younger (1613–1662), statesman, Puritan, son of Henry Vane the Elder
Henry Vane, 1st Earl of Darlington (c. 1705–1758) (c. 1705 – 6 March 1758), an English peer, the son of Gilbert Vane, 2nd Baron Barnard
Henry Vane, 2nd Earl of Darlington (1726–1792), English peer, the son of the 1st Earl
John Robert Vane (1927–2004), English pharmacologist, born in Tardebigg, Worcestershire
Mark Sutton Vane, English architectural lighting designer
Richard Fletcher-Vane, 2nd Baron Inglewood (b. 1951), Conservative Party politician in the United Kingdom, Member of the European Parliament (MEP) for Cumbria and Lancashire North from 1989 to 1994, and for North West England from 1999 to 2004
Robin Vane-Tempest-Stewart, 8th Marquess of Londonderry (1902–1955), Irish peer and politician
William Vane, 1st Duke of Cleveland (1766–1842), British peer
William Fletcher-Vane, 1st Baron Inglewood (1909–1989), British politician
Zachary A. Vane, American politician
