Van den Bossche or Vandenbossche is a Dutch surname originating in Flanders. It means either "from the woods" or "from Den Bosch". Notable people with the surname include:
Aert van den Bossche (fl. 1499-1505), Flemish painter
Agnes van den Bossche (c.1435 – c.1504), Flemish painter
Alain Van Den Bossche (born 1965), Belgian racing cyclist
Balthasar van den Bossche (1681–1715), Flemish painter
Bart van den Bossche (1964–2013), Flemish singer
Dany Vandenbossche (1956–2013), Belgian politician
Darla Vandenbossche (born 1963), Canadian actress
David Vandenbossche (born 1980), French footballer
Freya Van den Bossche (born 1975), Belgian politician
Gielis van den Bossche (c.1490 – after 1545), Flemish painter
Jules van den Bossche (1819–1889), Dutch military officer and colonial government official
Luc Van den Bossche (born 1947), Belgian politician
Martin Van Den Bossche (born 1941), Belgian bicycle racer
