Van den Bossche or Vandenbossche is a Dutch surname originating in Flanders. It means either "from the woods" or "from Den Bosch". Notable people with the surname include:
Aert van den Bossche (fl. 1499-1505), Flemish painterAgnes van den Bossche (c.1435 – c.1504), Flemish painterAlain Van Den Bossche (born 1965), Belgian racing cyclistBalthasar van den Bossche (1681–1715), Flemish painterBart van den Bossche (1964–2013), Flemish singerDany Vandenbossche (1956–2013), Belgian politicianDarla Vandenbossche (born 1963), Canadian actressDavid Vandenbossche (born 1980), French footballerFreya Van den Bossche (born 1975), Belgian politicianGielis van den Bossche (c.1490 – after 1545), Flemish painterJules van den Bossche (1819–1889), Dutch military officer and colonial government officialLuc Van den Bossche (born 1947), Belgian politicianMartin Van Den Bossche (born 1941), Belgian bicycle racer