van Wyk is a common Afrikaans surname, derived from the Dutch Van Wijk. Notable people with the surname include:
Abraham Erasmus van Wyk (born 1952), South African taxonomist
Arnold van Wyk (1916–1983), South African composer
Christopher van Wyk (1957–2014), South African writer
Coenie van Wyk (born 1988), South African rugby union player
Diaan van Wyk (born 1981), South African cricketer
Hermanus van Wyk (1835–1905), Namibian tribal chief
Inke van Wyk (born 1971), South African field hockey player
Jason van Wyk (born 1990), South African composer and record producer
Juandre van Wyk (born 1989), South African cricketer
Kruger van Wyk (born 1980), New Zealand cricketer
Lenert van Wyk (born 1989), South African cricketer
Morne van Wyk (born 1979), South African cricketer
N. P. van Wyk Louw (1906–1970), South African poet and playwright
Ruben Van Wyk (born 1976), Namibian footballer
