Van Hoogstraten is a Dutch toponymic surname, meaning "from Hoogstraten" and may apply to:
Jacob van Hoogstraten (c.1460–1527), Flemish Dominican theologian and controversialist
Dirk van Hoogstraten (1596-1640), Dutch painter
Samuel Dirksz van Hoogstraten (1627–1678), Dutch painter, poet and author on art theory
Jan van Hoogstraten (1628–1654), Dutch painter
For other descendants of Dirk van Hoogstraten, see Van Hoogstraten (family)
Willem van Hoogstraten (1884–1965), Dutch violinist and conductor
Jacob Emil van Hoogstraten (1898–1991), Dutch senior public servant in colonial Indonesia
Nicholas van Hoogstraten (born 1945), controversial British businessman
