Van Dyck or Vandyck is a Dutch surname. Notable people with the surname include:
Anthony van Dyck (1599–1641), Flemish artist, or the van Dyck beard named after him
Cornelius Van Alen Van Dyck (1819–1895), American missionary
Edouard Van Dyck (1918–1977), Belgian professional road bicycle racer
Elisabeth Van Dyck (1951–1979), German member of the Red Army Faction
Ernest van Dyck (1861–1923), Belgian dramatic tenor
Floris van Dyck (1575–1651), Dutch painter
Henry H. Van Dyck (1809–1888), New York politician
Jeff van Dyck (born 1969), Australian video game music composer
Jennifer Van Dyck (born 1962), Scottish television and film actress
Steve Van Dyck, Australian zoologist and museum curator
Vedder Van Dyck (1889–1960), American Episcopal bishop
William Vandyck, British actor and children's author
William V. B. Van Dyck (1875–1981), American football player, electrical engineer, and businessman