Van Doren is a toponymic surname of Dutch origin and a variation of Van Doorn. Notable people with the surname include:
Carl Clinton Van Doren (1885–1950), Pulitzer Prize-winning biographer, brother of Mark Van DorenCharles Van Doren (b. 1926), quiz show contestant, professor and Encyclopædia Britannica editor, son of Mark Van DorenDorothy Graffe Van Doren (1896–1993), American novelist, wife of Mark Van DorenHoward Van Doren Shaw (1869–1926), American architectIrita Bradford Van Doren (1891–1966), American literary figure and editor of the New York Herald Tribune, wife of Carl Clinton Van DorenPhilip Van Doren Stern (1900–1984), American author and Civil War historianMamie Van Doren (b. 1931), American actressMark Van Doren (1894–1972), Pulitzer Prize-winning poet and critic, brother of Carl Clinton Van DorenPaul Van Doren (b. 1930), American businessmanSally Van Doren, American poet