Van Doren is a toponymic surname of Dutch origin and a variation of Van Doorn. Notable people with the surname include:
Carl Clinton Van Doren (1885–1950), Pulitzer Prize-winning biographer, brother of Mark Van Doren
Charles Van Doren (b. 1926), quiz show contestant, professor and Encyclopædia Britannica editor, son of Mark Van Doren
Dorothy Graffe Van Doren (1896–1993), American novelist, wife of Mark Van Doren
Howard Van Doren Shaw (1869–1926), American architect
Irita Bradford Van Doren (1891–1966), American literary figure and editor of the New York Herald Tribune, wife of Carl Clinton Van Doren
Philip Van Doren Stern (1900–1984), American author and Civil War historian
Mamie Van Doren (b. 1931), American actress
Mark Van Doren (1894–1972), Pulitzer Prize-winning poet and critic, brother of Carl Clinton Van Doren
Paul Van Doren (b. 1930), American businessman
Sally Van Doren, American poet